Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal α5 integrin
NJ Gardiner, S Moffatt, P Fernyhough… - Molecular and Cellular …, 2007 - Elsevier
A preconditioning sciatic nerve crush promotes the capacity of adult sensory neurons to
regenerate following a subsequent injury to their axons. The increase in regeneration is
detected in cultures of dissociated neurons, as an earlier and enhanced rate of neurite
elongation. We compare neurotrophin-stimulated neurite outgrowth from sensory neurons
on laminin and fibronectin. There is a poor response of sensory neurons to fibronectin in
comparison to laminin, but this is enhanced by a preconditioning lesion to the sciatic nerve 7 …
regenerate following a subsequent injury to their axons. The increase in regeneration is
detected in cultures of dissociated neurons, as an earlier and enhanced rate of neurite
elongation. We compare neurotrophin-stimulated neurite outgrowth from sensory neurons
on laminin and fibronectin. There is a poor response of sensory neurons to fibronectin in
comparison to laminin, but this is enhanced by a preconditioning lesion to the sciatic nerve 7 …