Differential responses of human microglia and blood-derived myeloid cells to FTY720
BA Durafourt, C Lambert, TA Johnson, M Blain… - Journal of …, 2011 - Elsevier
Human microglia, monocyte-derived dendritic cells (DCs) and macrophages ex vivo express
relatively higher levels of sphingosine-1-phosphate (S1P) receptor 1 (S1P1) mRNA as
compared to other receptor subtypes. The S1P agonist FTY720 decreased ERK
phosphorylation and induced myosin light chain (MLC) II phosphorylation only in
macrophages and DCs. FTY720 inhibited IL-12p70 production (CD40L induced) by DCs
and macrophages but not microglia (poly I: C induced). IL-10 production was increased in …
relatively higher levels of sphingosine-1-phosphate (S1P) receptor 1 (S1P1) mRNA as
compared to other receptor subtypes. The S1P agonist FTY720 decreased ERK
phosphorylation and induced myosin light chain (MLC) II phosphorylation only in
macrophages and DCs. FTY720 inhibited IL-12p70 production (CD40L induced) by DCs
and macrophages but not microglia (poly I: C induced). IL-10 production was increased in …