[HTML][HTML] Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion

DJ Lo, DJ Anderson, TA Weaver, F Leopardi… - American Journal of …, 2013 - Elsevier
Belatacept is an inhibitor of CD28/B7 costimulation that is clinically indicated as a
calcineurin inhibitor (CNI) alternative in combination with mycophenolate mofetil and
steroids after renal transplantation. We sought to develop a clinically translatable,
nonlymphocyte depleting, belatacept-based regimen that could obviate the need for both
CNIs and steroids. Thus, based on murine data showing synergy between costimulation
blockade and mTOR inhibition, we studied rhesus monkeys undergoing MHC-mismatched …