Human dendritic cell 1 and dendritic cell 2 subsets express FcεRI: correlation with serum IgE and allergic asthma
B Foster, DD Metcalfe, C Prussin - Journal of Allergy and Clinical …, 2003 - Elsevier
BACKGROUND: Type 1 dendritic cells (DC1) express the high-affinity IgE receptor (FcεRI);
however, the regulation of FcεRI expression by DCs is not well understood. Type 2 DC
(DC2) expression of FcεRI has not been demonstrated. OBJECTIVE: We hypothesized that
DC2 cellsalso express FcεRI and that expression of FcεRI by the DC1 and DC2 subsets
correlates with serum IgE and allergic asthma disease status. METHODS: To test these
hypotheses, we quantitated FcεRI α chain expression by the peripheral blood precursor DC1 …
however, the regulation of FcεRI expression by DCs is not well understood. Type 2 DC
(DC2) expression of FcεRI has not been demonstrated. OBJECTIVE: We hypothesized that
DC2 cellsalso express FcεRI and that expression of FcεRI by the DC1 and DC2 subsets
correlates with serum IgE and allergic asthma disease status. METHODS: To test these
hypotheses, we quantitated FcεRI α chain expression by the peripheral blood precursor DC1 …