Riluzole elevates GLT-1 activity and levels in striatal astrocytes
M Carbone, S Duty, M Rattray - Neurochemistry international, 2012 - Elsevier
Drugs which upregulate astrocyte glutamate transport may be useful neuroprotective
compounds by preventing excitotoxicity. We set up a new system to identify potential
neuroprotective drugs which act through GLT-1. Primary mouse striatal astrocytes grown in
the presence of the growth-factor supplement G5 express high levels of the functional
glutamate transporter, GLT-1 (also known as EAAT2) as assessed by Western blotting and
3H-glutamate uptake assay, and levels decline following growth factor withdrawal. The GLT …
compounds by preventing excitotoxicity. We set up a new system to identify potential
neuroprotective drugs which act through GLT-1. Primary mouse striatal astrocytes grown in
the presence of the growth-factor supplement G5 express high levels of the functional
glutamate transporter, GLT-1 (also known as EAAT2) as assessed by Western blotting and
3H-glutamate uptake assay, and levels decline following growth factor withdrawal. The GLT …
