[HTML][HTML] Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes

SG Lee, ZZ Su, L Emdad, P Gupta, D Sarkar… - Journal of Biological …, 2008 - ASBMB
Glutamate is an essential neurotransmitter regulating brain functions. Excitatory amino acid
transporter (EAAT)-2 is one of the major glutamate transporters primarily expressed in
astroglial cells. Dysfunction of EAAT2 is implicated in acute and chronic neurological
disorders, including stroke/ischemia, temporal lobe epilepsy, amyotrophic lateral sclerosis,
Alzheimer disease, human immunodeficiency virus 1-associated dementia, and growth of
malignant gliomas. Ceftriaxone, one of the β-lactam antibiotics, is a stimulator of EAAT2 …