Peripheral pharmacokinetic parameters of levodopa/carbidopa and the on-off phenomenon in parkinsonian patients
I Rainero, M Gilli, T De Gennaro, I Chiado… - The Italian Journal of …, 1988 - Springer
I Rainero, M Gilli, T De Gennaro, I Chiado, M Delsedime, A Riccio, B Bergamasco
The Italian Journal of Neurological Sciences, 1988•SpringerThe principal peripheral pharmacokinetic parameters of the levodopa/carbidopa association
were investigated in 11 healthy volunteers and in 16 patients at various stages of Parkinson
disease, with and without the on-off phenomenon. After oral administration of a standard
dose of drug (levodopa 250 mg+ carbidopa 25 mg) the peak plasma concentrations, peak
onset time and area under the curve/time proved to be similar across the groups. There was
no difference in peripheral pharmacokinetics of the association between parkinsonian …
were investigated in 11 healthy volunteers and in 16 patients at various stages of Parkinson
disease, with and without the on-off phenomenon. After oral administration of a standard
dose of drug (levodopa 250 mg+ carbidopa 25 mg) the peak plasma concentrations, peak
onset time and area under the curve/time proved to be similar across the groups. There was
no difference in peripheral pharmacokinetics of the association between parkinsonian …
Abstract
The principal peripheral pharmacokinetic parameters of the levodopa/carbidopa association were investigated in 11 healthy volunteers and in 16 patients at various stages of Parkinson disease, with and without the on-off phenomenon. After oral administration of a standard dose of drug (levodopa 250 mg + carbidopa 25 mg) the peak plasma concentrations, peak onset time and area under the curve/time proved to be similar across the groups. There was no difference in peripheral pharmacokinetics of the association between parkinsonian patients with swings in response and those without.
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