Functional characterization of the brain-to-blood efflux clearance of human amyloid-β peptide (1–40) across the rat blood–brain barrier
S Ito, S Ohtsuki, T Terasaki - Neuroscience research, 2006 - Elsevier
The present study sought to characterize the brain-to-blood efflux transport of human
amyloid-β peptide (hAβ)(1–40) across the blood–brain barrier (BBB) in rats. We determined
the apparent brain-to-blood [125I] hAβ (1–40) efflux clearance in rats and found it to be 11.0
μL/(ming brain). There were no significant gender differences in the apparent brain-to-blood
[125I] hAβ (1–40) efflux clearance. The brain-to-blood [125I] hAβ (1–40) efflux transport was
significantly inhibited by unlabeled hAβ (1–40) and hAβ (1–42) by 79.1% and 36.4 …
amyloid-β peptide (hAβ)(1–40) across the blood–brain barrier (BBB) in rats. We determined
the apparent brain-to-blood [125I] hAβ (1–40) efflux clearance in rats and found it to be 11.0
μL/(ming brain). There were no significant gender differences in the apparent brain-to-blood
[125I] hAβ (1–40) efflux clearance. The brain-to-blood [125I] hAβ (1–40) efflux transport was
significantly inhibited by unlabeled hAβ (1–40) and hAβ (1–42) by 79.1% and 36.4 …