Time course of the hypothermic response to continuously administered neurotensin
E Popp, A Schneider, P Vogel, P Teschendorf… - Neuropeptides, 2007 - Elsevier
Intracerebroventricular administration of the tridecapeptide neurotensin is known to elicit
hypothermia in rodents for few hours. In the present study, we investigated a continuous
intracerebroventricular infusion regimen for prolongation of the hypothermic effect. Male
Wistar-Han rats (n= 13) received neurotensin 10–50μg/h for 48h, while their body
temperature was monitored continuously. This protocol led to a dose-dependent decrease of
body temperature down to 35–36° C. The nadir of hypothermia lasted for approximately 4h …
hypothermia in rodents for few hours. In the present study, we investigated a continuous
intracerebroventricular infusion regimen for prolongation of the hypothermic effect. Male
Wistar-Han rats (n= 13) received neurotensin 10–50μg/h for 48h, while their body
temperature was monitored continuously. This protocol led to a dose-dependent decrease of
body temperature down to 35–36° C. The nadir of hypothermia lasted for approximately 4h …