[HTML][HTML] The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation
The β subunit cytoplasmic domains of integrin adhesion receptors are necessary for the
connection of these receptors to the actin cytoskeleton. The cytoplasmic protein, talin, binds
to β integrin cytoplasmic tails and actin filaments, hence forming an integrin-cytoskeletal
linkage. We used recombinant structural mimics of β 1 A, β 1 D and β 3 integrin cytoplasmic
tails to characterize integrin-binding sites within talin. Here we report that an integrin-binding
site is localized within the N-terminal talin head domain. The binding of the talin head …
connection of these receptors to the actin cytoskeleton. The cytoplasmic protein, talin, binds
to β integrin cytoplasmic tails and actin filaments, hence forming an integrin-cytoskeletal
linkage. We used recombinant structural mimics of β 1 A, β 1 D and β 3 integrin cytoplasmic
tails to characterize integrin-binding sites within talin. Here we report that an integrin-binding
site is localized within the N-terminal talin head domain. The binding of the talin head …