Neuronal regulation of alternative pre-mRNA splicing
Q Li, JA Lee, DL Black - Nature Reviews Neuroscience, 2007 - nature.com
Q Li, JA Lee, DL Black
Nature Reviews Neuroscience, 2007•nature.comAlternative pre-mRNA splicing has an important role in the control of neuronal gene
expression. Many neuronal proteins are structurally diversified through the differential
inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common
mechanisms of splicing regulation and provide examples of how alternative splicing has
important roles in neuronal development and mature neuron function. Finally, we describe
regulatory proteins that control the splicing of some neuronally expressed transcripts.
expression. Many neuronal proteins are structurally diversified through the differential
inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common
mechanisms of splicing regulation and provide examples of how alternative splicing has
important roles in neuronal development and mature neuron function. Finally, we describe
regulatory proteins that control the splicing of some neuronally expressed transcripts.
Abstract
Alternative pre-mRNA splicing has an important role in the control of neuronal gene expression. Many neuronal proteins are structurally diversified through the differential inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common mechanisms of splicing regulation and provide examples of how alternative splicing has important roles in neuronal development and mature neuron function. Finally, we describe regulatory proteins that control the splicing of some neuronally expressed transcripts.
nature.com