Donor-specific antibodies to human leukocyte antigens are associated with and precede antibodies to major histocompatibility complex class I–related chain A in …

DS Nath, N Angaswamy, HI Basha, D Phelan… - Human immunology, 2010 - Elsevier
Humoral immune responses to mismatched donor human leukocyte antigen (HLA) and
major histocompatibility complex (MHC) class I–related chain A (MICA) have been reported
to contribute to immunopathogenesis of antibody-mediated rejection (AMR) in the early
period and cardiac allograft vasculopathy (CAV) in the late period after cardiac
transplantation (HTx). The goal of this study is to define the roles of donor-specific antibodies
(DSA) and anti-MICA in AMR and CAV. A total of 95 post-HTx recipients were enrolled; 43 …