Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries
S Mauiyyedi, P Della Pelle, S Saidman… - Journal of the …, 2001 - journals.lww.com
The pathogenesis of chronic renal allograft rejection (CR) remains obscure. The hypothesis
that a subset of CR is mediated by antidonor antibody was tested by determining whether
C4d is deposited in peritubular capillaries (PTC) and whether it correlates with circulating
antidonor antibodies. All cases (from January 1, 1990, to July 31, 1999) that met histologic
criteria for CR and had frozen tissue (28 biopsies, 10 nephrectomies) were included.
Controls were renal allograft biopsies with chronic cyclosporine toxicity (n= 21) or …
that a subset of CR is mediated by antidonor antibody was tested by determining whether
C4d is deposited in peritubular capillaries (PTC) and whether it correlates with circulating
antidonor antibodies. All cases (from January 1, 1990, to July 31, 1999) that met histologic
criteria for CR and had frozen tissue (28 biopsies, 10 nephrectomies) were included.
Controls were renal allograft biopsies with chronic cyclosporine toxicity (n= 21) or …