Hyaluronan–magic glue for the regulation of the immune response?
C Termeer, JP Sleeman, JC Simon - TRENDS in Immunology, 2003 - cell.com
C Termeer, JP Sleeman, JC Simon
TRENDS in Immunology, 2003•cell.comThe extracellular matrix-filling material hyaluronan (HA) can modulate the function of antigen-
presenting cells, such as dendritic cells (DCs) and macrophages. Recent studies show that
DCs are actively involved in this process by expressing HA synthesizing and degrading
enzymes. T cells also express these enzymes and require HA to bind to their surface in
order to become activated.
presenting cells, such as dendritic cells (DCs) and macrophages. Recent studies show that
DCs are actively involved in this process by expressing HA synthesizing and degrading
enzymes. T cells also express these enzymes and require HA to bind to their surface in
order to become activated.
Abstract
The extracellular matrix-filling material hyaluronan (HA) can modulate the function of antigen-presenting cells, such as dendritic cells (DCs) and macrophages. Recent studies show that DCs are actively involved in this process by expressing HA synthesizing and degrading enzymes. T cells also express these enzymes and require HA to bind to their surface in order to become activated.
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