Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

JL Clements, B Yang, SE Ross-Barta, SL Eliason… - Science, 1998 - science.org
JL Clements, B Yang, SE Ross-Barta, SL Eliason, RF Hrstka, RA Williamson, GA Koretzky
Science, 1998science.org
The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain–containing
leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after
receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-
76 expression contained no peripheral T cells as a result of an early block in thymopoiesis.
Macrophage and natural killer cell compartments were intact in SLP-76–deficient mice,
despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter …
The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain–containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76–deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre–T cell receptors into distal biochemical events.
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