[HTML][HTML] Inflammation-induced Uptake and Degradation of the Lymphatic Endothelial Hyaluronan Receptor LYVE-1*♦
LA Johnson, R Prevo, S Clasper, DG Jackson - Journal of Biological …, 2007 - ASBMB
The hyaluronan receptor LYVE-1 is selectively expressed in the endothelium of lymphatic
capillaries, where it has been proposed to function in hyaluronan clearance and hyaluronan-
mediated leukocyte adhesion. However, recent studies suggest that hyaluronan
homeostasis is unperturbed in LYVE-1-/-mice and that lymphatic adhesion/transmigration
may be largely mediated by ICAM-1 and VCAM-1 rather than LYVE-1. Here we have
explored the possibility that LYVE-1 functions during inflammation and report that the …
capillaries, where it has been proposed to function in hyaluronan clearance and hyaluronan-
mediated leukocyte adhesion. However, recent studies suggest that hyaluronan
homeostasis is unperturbed in LYVE-1-/-mice and that lymphatic adhesion/transmigration
may be largely mediated by ICAM-1 and VCAM-1 rather than LYVE-1. Here we have
explored the possibility that LYVE-1 functions during inflammation and report that the …