Breast cancer prognosis and occult lymph node metastases, isolated tumor cells, and micrometastases
M de Boer, JAAM van Dijck, P Bult… - Journal of the …, 2010 - academic.oup.com
M de Boer, JAAM van Dijck, P Bult, GF Borm, VCG Tjan-Heijnen
Journal of the National Cancer Institute, 2010•academic.oup.comBackground The prognostic relevance of isolated tumor cells and micrometastases in lymph
nodes from patients with breast cancer has become a major issue since the introduction of
the sentinel lymph node procedure. We conducted a systematic review of this issue.
Methods Studies published from January 1, 1977, until August 11, 2008, were identified by
use of MEDLINE, EMBASE, and the Cochrane Library. A total of 58 studies (total number of
patients= 297 533) were included and divided into three categories according to the method …
nodes from patients with breast cancer has become a major issue since the introduction of
the sentinel lymph node procedure. We conducted a systematic review of this issue.
Methods Studies published from January 1, 1977, until August 11, 2008, were identified by
use of MEDLINE, EMBASE, and the Cochrane Library. A total of 58 studies (total number of
patients= 297 533) were included and divided into three categories according to the method …
Background
The prognostic relevance of isolated tumor cells and micrometastases in lymph nodes from patients with breast cancer has become a major issue since the introduction of the sentinel lymph node procedure. We conducted a systematic review of this issue.
Methods
Studies published from January 1, 1977, until August 11, 2008, were identified by use of MEDLINE, EMBASE, and the Cochrane Library. A total of 58 studies (total number of patients = 297 533) were included and divided into three categories according to the method for pathological assessment of the lymph nodes: cohort studies with single-section pathological examination of axillary lymph nodes (n = 285 638 patients), occult metastases studies with retrospective examination of negative lymph nodes by step sectioning and/or immunohistochemistry (n = 7740 patients), and sentinel lymph node biopsy studies with intensified work-up of the sentinel but not of the nonsentinel lymph nodes (n = 4155 patients). We used random-effects meta-analyses to calculate pooled estimates of the relative risks (RRs) of 5- and 10-year disease recurrence and death and the multivariably corrected pooled hazard ratio (HR) of overall survival of the cohort studies.
Results
In the cohort studies, the presence (vs the absence) of metastases of 2 mm or less in diameter in axillary lymph nodes was associated with poorer overall survival (pooled HR of death = 1.44, 95% confidence interval [CI] = 1.29 to 1.62). In the occult metastases studies, the presence (vs the absence) of occult metastases was associated with poorer 5-year disease-free survival (pooled RR = 1.55, 95% CI = 1.32 to 1.82) and overall survival (pooled RR = 1.45, 95% CI = 1.11 to 1.88), although these endpoints were not consistently assessed in multivariable analyses. Sentinel lymph node biopsy studies were limited by small patient groups and short follow-up.
Conclusion
The presence (vs the absence) of metastases of 2 mm or less in diameter in axillary lymph nodes detected on single-section examination was associated with poorer disease-free and overall survival.
Oxford University Press