SGLT2 mediates glucose reabsorption in the early proximal tubule
V Vallon, KA Platt, R Cunard, J Schroth… - Journal of the …, 2011 - journals.lww.com
Mutations in the gene encoding for the Na+-glucose co-transporter SGLT2 (SLC5A2)
associate with familial renal glucosuria, but the role of SGLT2 in the kidney is incompletely
understood. Here, we determined the localization of SGLT2 in the mouse kidney and
generated and characterized SGLT2-deficient mice. In wild-type (WT) mice,
immunohistochemistry localized SGLT2 to the brush border membrane of the early proximal
tubule. Sglt2−/− mice had glucosuria, polyuria, and increased food and fluid intake without …
associate with familial renal glucosuria, but the role of SGLT2 in the kidney is incompletely
understood. Here, we determined the localization of SGLT2 in the mouse kidney and
generated and characterized SGLT2-deficient mice. In wild-type (WT) mice,
immunohistochemistry localized SGLT2 to the brush border membrane of the early proximal
tubule. Sglt2−/− mice had glucosuria, polyuria, and increased food and fluid intake without …