Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals
M Matsuda, RA DeFronzo, L Glass… - Metabolism …, 2002 - metabolismjournal.com
This study sought to examine whether enhanced hepatic sensitivity to glucagon contributes
to impaired glucose homeostasis in subjects with type 2 diabetes mellitus (T2DM). Eight
T2DM and 9 age-, weight-, and gender-matched nondiabetic subjects received a 4-hour
glucagon infusion at the rates of 0.2, 0.5, 2, 6, and 8 ng [middot] kg [minus] 1 [middot] min
[minus] 1 while maintaining the plasma insulin concentration constant at the basal level with
exogenous infusions of somatostatin and insulin. On the evening prior to study, diabetic …
to impaired glucose homeostasis in subjects with type 2 diabetes mellitus (T2DM). Eight
T2DM and 9 age-, weight-, and gender-matched nondiabetic subjects received a 4-hour
glucagon infusion at the rates of 0.2, 0.5, 2, 6, and 8 ng [middot] kg [minus] 1 [middot] min
[minus] 1 while maintaining the plasma insulin concentration constant at the basal level with
exogenous infusions of somatostatin and insulin. On the evening prior to study, diabetic …