Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages

D Töröcsik, A Szanto, L Nagy - Molecular aspects of medicine, 2009 - Elsevier
Sterols and fatty acids are common intermediary metabolites in all cells of the body.
Oxidative modifications of these molecules can occur and result in the production of
oxysterols and oxidized fatty acids. Significantly, these modified molecules not only
participate in basic metabolic processes but they are also involved in signaling pathways.
These two groups of molecules are known to regulate the activity of a special group of ligand-
activated transcription factors, known as nuclear receptors. Oxysterols activate liver X …