[HTML][HTML] Abnormalities of T cell signaling in systemic lupus erythematosus

VR Moulton, GC Tsokos - Arthritis research & therapy, 2011 - Springer
VR Moulton, GC Tsokos
Arthritis research & therapy, 2011Springer
Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of
tolerance to multiple self antigens, and characterized by autoantibody production and
inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are
critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate
target tissues, leading to tissue damage. Abnormal signaling events link to defective gene
transcription and altered cytokine production, contributing to the aberrant phenotype of T …
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate target tissues, leading to tissue damage. Abnormal signaling events link to defective gene transcription and altered cytokine production, contributing to the aberrant phenotype of T cells in SLE. Study of signaling and gene transcription abnormalities in SLE T cells has led to the identification of novel targets for therapy.
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