Treating asthma means treating airway smooth muscle cells
S Zuyderduyn, MB Sukkar, A Fust… - European …, 2008 - Eur Respiratory Soc
S Zuyderduyn, MB Sukkar, A Fust, S Dhaliwal, JK Burgess
European Respiratory Journal, 2008•Eur Respiratory SocAsthma is characterised by airway hyperresponsiveness, airway inflammation and airway
remodelling. Airway smooth muscle cells are known to be the main effector cells of airway
narrowing. In the present paper, studies will be discussed that have led to a novel view of
the role of airway smooth muscle in the pathogenesis of asthma in which airway
hyperresponsiveness, remodelling and inflammation are, at least in part, attributable to
airway smooth muscle. Furthermore, how this new view may lead to a change in the …
remodelling. Airway smooth muscle cells are known to be the main effector cells of airway
narrowing. In the present paper, studies will be discussed that have led to a novel view of
the role of airway smooth muscle in the pathogenesis of asthma in which airway
hyperresponsiveness, remodelling and inflammation are, at least in part, attributable to
airway smooth muscle. Furthermore, how this new view may lead to a change in the …
Asthma is characterised by airway hyperresponsiveness, airway inflammation and airway remodelling. Airway smooth muscle cells are known to be the main effector cells of airway narrowing. In the present paper, studies will be discussed that have led to a novel view of the role of airway smooth muscle in the pathogenesis of asthma in which airway hyperresponsiveness, remodelling and inflammation are, at least in part, attributable to airway smooth muscle. Furthermore, how this new view may lead to a change in the phenotyping and treatment of patients with asthma will be discussed.
European Respiratory Society