Disruption of neuronal CXCR4 function by opioids: preliminary evidence of ferritin heavy chain as a potential etiological agent in neuroAIDS
J Pitcher, S Shimizu, S Burbassi, O Meucci - Journal of neuroimmunology, 2010 - Elsevier
The chemokine CXCL12 and its receptor, CXCR4, regulate neuronal migration,
differentiation, and survival. Alterations of CXCL12/CXCR4 signaling are implicated in
different neuropathologies, including the neurological complications of HIV infection.
Opiates are important co-factors for progression to neuroAIDS and can disrupt the
CXCL12/CXCR4 axis in vitro and in vivo. This paper will review recently identified
mechanisms of opiate-induced CXCR4 impairment in neurons and introduce results from …
differentiation, and survival. Alterations of CXCL12/CXCR4 signaling are implicated in
different neuropathologies, including the neurological complications of HIV infection.
Opiates are important co-factors for progression to neuroAIDS and can disrupt the
CXCL12/CXCR4 axis in vitro and in vivo. This paper will review recently identified
mechanisms of opiate-induced CXCR4 impairment in neurons and introduce results from …