[HTML][HTML] Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and …

R Li, C Luo, M Mines, J Zhang, GH Fan - Journal of biological chemistry, 2006 - ASBMB
Chemokine receptor-initiated signaling plays critical roles in cell differentiation, proliferation,
and migration. However, the regulation of chemokine receptor signaling under physiological
and pathological conditions is not fully understood. In the present study, we demonstrate that
the CXC chemokine receptor 4 (CXCR4) formed a complex with ferritin heavy chain (FHC) in
a ligand-dependent manner. Our in vitro binding assays revealed that purified FHC
associated with both the glutathione S-transferase-conjugated N-terminal and C-terminal …