Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the κ-opioid receptor
MJ Finley, X Chen, G Bardi, P Davey, EB Geller… - Journal of …, 2008 - Elsevier
We previously characterized multiple interactions between chemokine and opioid G protein-
coupled receptors (GPCR), and we found both μ and δ-opioid receptors cross-desensitize
CCR1, CCR2, CCR5, but not CXCR4. Here we report that the κ-opioid receptor (KOR) is
able to cross-desensitize CXCR4, and this phenomenon is bi-directional. Chemotactic
responses by KOR activation are diminished with prior activation of CXCR4. Additionally,
calcium mobilization assays show these cross-desensitization processes occur within …
coupled receptors (GPCR), and we found both μ and δ-opioid receptors cross-desensitize
CCR1, CCR2, CCR5, but not CXCR4. Here we report that the κ-opioid receptor (KOR) is
able to cross-desensitize CXCR4, and this phenomenon is bi-directional. Chemotactic
responses by KOR activation are diminished with prior activation of CXCR4. Additionally,
calcium mobilization assays show these cross-desensitization processes occur within …