Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron
T Šimůnek, M Štěrba, O Popelová, M Adamcová… - Pharmacological …, 2009 - Elsevier
The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of
anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin),
daunorubicin or epirubicin. Nevertheless, these compounds remain among the most widely
used anticancer drugs. The molecular pathogenesis of anthracycline cardiotoxicity remains
highly controversial, although the oxidative stress-based hypothesis involving
intramyocardial production of reactive oxygen species (ROS) has gained the widest …
anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin),
daunorubicin or epirubicin. Nevertheless, these compounds remain among the most widely
used anticancer drugs. The molecular pathogenesis of anthracycline cardiotoxicity remains
highly controversial, although the oxidative stress-based hypothesis involving
intramyocardial production of reactive oxygen species (ROS) has gained the widest …