Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior

JI Choi, CI Svensson, FJ Koehrn, A Bhuskute… - PAINŽ, 2010 - Elsevier
In the present study, intraplantar carrageenan induced increased mechanical allodynia,
phosphorylation of PKB/Akt and GluR1 ser 845 (PKA site) as well as GluR1, but not GluR2
movement into neuronal membranes. This change in membrane GluR1/GluR2 ratio is
indicative of Ca2+ permeable AMPA receptor insertion. Pain behavior was reduced and
biochemical changes blocked by spinal pretreatment, but not post-treatment, with a tumor
necrosis factor (TNF) antagonist, Etanercept (100μg). Pain behavior was also reduced by …