Over-expression of Flt3 induces NF-κB pathway and increases the expression of IL-6
S Takahashi, H Harigae, KK Ishii, M Inomata… - Leukemia research, 2005 - Elsevier
Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic
leukemia (AML), associated with activation of Ras/MAP kinase and other signaling
pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-
kappa B (NF-κB), which is a target molecule of these kinase pathways. In BaF3 cells stably
expressing Flt3, a NF-κB-responsive reporter was upregulated and its target gene, IL-6, was
increased by the involvement of Flt3-ERK/MAPK-NF-κB pathway. Furthermore, we found a …
leukemia (AML), associated with activation of Ras/MAP kinase and other signaling
pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-
kappa B (NF-κB), which is a target molecule of these kinase pathways. In BaF3 cells stably
expressing Flt3, a NF-κB-responsive reporter was upregulated and its target gene, IL-6, was
increased by the involvement of Flt3-ERK/MAPK-NF-κB pathway. Furthermore, we found a …