[HTML][HTML] The oncoprotein Ski acts as an antagonist of transforming growth factor-β signaling by suppressing Smad2 phosphorylation
C Prunier, M Pessah, N Ferrand, SR Seo… - Journal of Biological …, 2003 - ASBMB
The phosphorylation of Smad2 and Smad3 by the transforming growth factor (TGF)-β-
activated receptor kinases and their subsequent heterodimerization with Smad4 and
translocation to the nucleus form the basis for a model how Smad proteins work to transmit
TGF-β signals. The transcriptional activity of Smad2-Smad4 or Smad3-Smad4 complexes
can be limited by the corepressor Ski, which is believed to interact with Smad complexes on
TGF-β-responsive promoters and represses their ability to activate TGF-β target genes by …
activated receptor kinases and their subsequent heterodimerization with Smad4 and
translocation to the nucleus form the basis for a model how Smad proteins work to transmit
TGF-β signals. The transcriptional activity of Smad2-Smad4 or Smad3-Smad4 complexes
can be limited by the corepressor Ski, which is believed to interact with Smad complexes on
TGF-β-responsive promoters and represses their ability to activate TGF-β target genes by …