[HTML][HTML] Proteolysis of latent transforming growth factor-β (TGF-β)-binding protein-1 by osteoclasts: a cellular mechanism for release of TGF-β from bone matrix
SL Dallas, JL Rosser, GR Mundy… - Journal of Biological …, 2002 - ASBMB
The binding of growth factors to the extracellular matrix (ECM) may be a key pathway for
regulation of their activity. We have shown that a major mechanism for storage of
transforming growth factor-β (TGF-β) in bone ECM is via its association with latent TGF-β-
binding protein-1 (LTBP1). Although proteolytic cleavage of LTBP1 has been reported, it
remains unclear whether this represents a physiological mechanism for release of matrix-
bound TGF-β. Here we examined the role of LTBP1 in cell-mediated release of TGF-β from …
regulation of their activity. We have shown that a major mechanism for storage of
transforming growth factor-β (TGF-β) in bone ECM is via its association with latent TGF-β-
binding protein-1 (LTBP1). Although proteolytic cleavage of LTBP1 has been reported, it
remains unclear whether this represents a physiological mechanism for release of matrix-
bound TGF-β. Here we examined the role of LTBP1 in cell-mediated release of TGF-β from …