[HTML][HTML] Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of …
RK Reddy, C Mao, P Baumeister, RC Austin… - Journal of Biological …, 2003 - ASBMB
A large number of correlative studies have established that the activation of the unfolded
protein response (UPR) alters the cell's sensitivity to chemotherapeutic agents. Although the
induction of the glucose-regulated proteins (GRPs) is commonly used as an indicator for the
UPR, the direct role of the GRPs in conferring resistance to DNA damaging agents has not
been proven. We report here that without the use of endoplasmic reticulum (ER) stress
inducers, specific overexpression of GRP78 results in reduced apoptosis and higher colony …
protein response (UPR) alters the cell's sensitivity to chemotherapeutic agents. Although the
induction of the glucose-regulated proteins (GRPs) is commonly used as an indicator for the
UPR, the direct role of the GRPs in conferring resistance to DNA damaging agents has not
been proven. We report here that without the use of endoplasmic reticulum (ER) stress
inducers, specific overexpression of GRP78 results in reduced apoptosis and higher colony …