[HTML][HTML] Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo
N Fukuhara, JA Howitt, SA Hussain… - Journal of Biological …, 2008 - ASBMB
Recognition of the secreted protein Slit by transmembrane receptors of the Robo family
provides important signals in the development of the nervous system and other organs, as
well as in tumor metastasis and angiogenesis. Heparan sulfate (HS) proteoglycans serve as
essential co-receptors in Slit-Robo signaling. Previous studies have shown that the second
leucinerich repeat domain of Slit, D2, binds to the N-terminal immunoglobulin-like domains
of Robo, IG1-2. Here we present two crystal structures of Drosophila Robo IG1-2, one of …
provides important signals in the development of the nervous system and other organs, as
well as in tumor metastasis and angiogenesis. Heparan sulfate (HS) proteoglycans serve as
essential co-receptors in Slit-Robo signaling. Previous studies have shown that the second
leucinerich repeat domain of Slit, D2, binds to the N-terminal immunoglobulin-like domains
of Robo, IG1-2. Here we present two crystal structures of Drosophila Robo IG1-2, one of …