[HTML][HTML] The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein …

AP Sjoberg, LA Trouw, SJ Clark, J Sjolander… - Journal of Biological …, 2007 - ASBMB
Recently, a polymorphism in the complement regulator factor H (FH) gene has been
associated with age-related macular degeneration. When histidine instead of tyrosine is
present at position 384 in the seventh complement control protein (CCP) domain of FH, the
risk for age-related macular degeneration is increased. It was recently shown that these
allotypic variants of FH, in the context of a recombinant construct corresponding to CCPs 6–
8, recognize polyanionic structures differently, which may lead to altered regulation of the …