Mangafodipir prevents liver injury induced by acetaminophen in the mouse
S Bedda, A Laurent, F Conti, C Chéreau, A Tran… - Journal of …, 2003 - Elsevier
Background/Aims: Acute liver failure (ALF), characterized by massive hepatocyte necrosis, is
often caused by drug poisoning, particularly with acetaminophen (APAP). Hepatocyte
necrosis is consecutive to glutathione depletion by NAPQI, a metabolite of APAP, and to
mitochondrial damages caused by reactive oxygen species (ROS) overproduction.
Considering the structure of Mangafodipir, a contrast agent currently used in magnetic
resonance imaging of the liver, we hypothesized that this molecule could exert an …
often caused by drug poisoning, particularly with acetaminophen (APAP). Hepatocyte
necrosis is consecutive to glutathione depletion by NAPQI, a metabolite of APAP, and to
mitochondrial damages caused by reactive oxygen species (ROS) overproduction.
Considering the structure of Mangafodipir, a contrast agent currently used in magnetic
resonance imaging of the liver, we hypothesized that this molecule could exert an …