[HTML][HTML] Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2
KR Taylor, K Yamasaki, KA Radek, A Di Nardo… - Journal of Biological …, 2007 - ASBMB
Inflammation under sterile conditions is not well understood despite its importance in trauma
and autoimmune disease. To investigate this process we established mouse models of
sterile injury and explored the role of hyaluronan in mediating inflammation following injury.
The response of cultured monocytes to hyaluronan was different than the response to
lipopolysaccharide (LPS) despite both being dependent on Toll-like receptor 4 (TLR4).
Cultured cells exposed to hyaluronan showed a pattern of gene induction that mimics the …
and autoimmune disease. To investigate this process we established mouse models of
sterile injury and explored the role of hyaluronan in mediating inflammation following injury.
The response of cultured monocytes to hyaluronan was different than the response to
lipopolysaccharide (LPS) despite both being dependent on Toll-like receptor 4 (TLR4).
Cultured cells exposed to hyaluronan showed a pattern of gene induction that mimics the …