Serum C′ 3 lytic system in patients with glomerulonephritis
RE Spitzer, EH Vallota, J Forristal, E Sudora, A Stitzel… - Science, 1969 - science.org
RE Spitzer, EH Vallota, J Forristal, E Sudora, A Stitzel, NC Davis, CD West
Science, 1969•science.orgThe serums of patients with hypocomplementemic glomerulonephritis contain a substance
that combines with a normal serum cofactor in the presence of magnesium ion to specifically
cleave the third component of complement. This lysis of C′ 3 is 80 to 90 percent complete
in 20 minutes at 37° C and p H 7. Neither the nephritic factor nor its cofactor is identifiable
with the complement system.
that combines with a normal serum cofactor in the presence of magnesium ion to specifically
cleave the third component of complement. This lysis of C′ 3 is 80 to 90 percent complete
in 20 minutes at 37° C and p H 7. Neither the nephritic factor nor its cofactor is identifiable
with the complement system.
The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C′3 is 80 to 90 percent complete in 20 minutes at 37°C and pH 7. Neither the nephritic factor nor its cofactor is identifiable with the complement system.
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