[HTML][HTML] The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases
MB Laederich, M Funes-Duran, L Yen, E Ingalla… - Journal of Biological …, 2004 - ASBMB
The molecular mechanisms by which mammalian receptor tyrosine kinases are negatively
regulated remain largely unexplored. Previous genetic and biochemical studies indicate that
Kekkon-1, a transmembrane protein containing leucine-rich repeats and an immunoglobulin-
like domain in its extracellular region, acts as a feedback negative regulator of epidermal
growth factor (EGF) receptor signaling in Drosophila melanogaster development. Here we
tested whether the related human LRIG1 (also called Lig-1) protein can act as a negative …
regulated remain largely unexplored. Previous genetic and biochemical studies indicate that
Kekkon-1, a transmembrane protein containing leucine-rich repeats and an immunoglobulin-
like domain in its extracellular region, acts as a feedback negative regulator of epidermal
growth factor (EGF) receptor signaling in Drosophila melanogaster development. Here we
tested whether the related human LRIG1 (also called Lig-1) protein can act as a negative …