Targeted disruption of LIG‐1 gene results in psoriasiform epidermal hyperplasia 1

Y Suzuki, H Miura, A Tanemura, K Kobayashi… - FEBS …, 2002 - Wiley Online Library
Y Suzuki, H Miura, A Tanemura, K Kobayashi, G Kondoh, S Sano, K Ozawa, S Inui, A Nakata…
FEBS letters, 2002Wiley Online Library
The gene encoding a transmembrane glycoprotein LIG‐1, of which the extracellular region
was organized with the leucine‐rich repeats and immunoglobulin‐like domains, was
disrupted in mice by gene targeting. LIG‐1‐deficient mice developed a skin change on the
tail and facial area after birth. The affected skin was histologically reminiscent of the
epidermis in human common skin disease 'psoriasis'. LIG‐1 was expressed in basal cells of
the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG‐1 …
The gene encoding a transmembrane glycoprotein LIG‐1, of which the extracellular region was organized with the leucine‐rich repeats and immunoglobulin‐like domains, was disrupted in mice by gene targeting. LIG‐1‐deficient mice developed a skin change on the tail and facial area after birth. The affected skin was histologically reminiscent of the epidermis in human common skin disease ‘psoriasis’. LIG‐1 was expressed in basal cells of the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG‐1 expression was apparently down‐regulated in the psoriatic lesions, suggesting that LIG‐1 inversely correlates with proliferative ability of epidermal keratinocytes.
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