Tissue morphogenesis and homeostasis are dependent on a complex dialogue between
multiple cell types and chemical and physical cues in the surrounding microenvironment.
The emergence of engineered three‐dimensional (3D) tissue constructs and the
development of tractable methods to recapitulate the native tissue microenvironment ex vivo
has led to a deeper understanding of tissue‐specific behavior. However, much remains
unclear about how the microenvironment and aberrations therein directly affect tissue …