[HTML][HTML] Specificity of TRAF3 in its negative regulation of the noncanonical NF-κB pathway
JQ He, SK Saha, JR Kang, B Zarnegar… - Journal of biological …, 2007 - ASBMB
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are critical signaling
adaptors downstream of many receptors in the TNF receptor and interleukin-1 receptor/Toll-
like receptor superfamilies. Whereas TRAF2, 5, and 6 are activators of the canonical NF-κB
signaling pathway, TRAF3 is an inhibitor of the noncanonical NF-κB pathway. The
contribution of the different domains in TRAFs to their respective functions remains unclear.
To elucidate the structural and functional specificities of TRAF3, we reconstituted TRAF3 …
adaptors downstream of many receptors in the TNF receptor and interleukin-1 receptor/Toll-
like receptor superfamilies. Whereas TRAF2, 5, and 6 are activators of the canonical NF-κB
signaling pathway, TRAF3 is an inhibitor of the noncanonical NF-κB pathway. The
contribution of the different domains in TRAFs to their respective functions remains unclear.
To elucidate the structural and functional specificities of TRAF3, we reconstituted TRAF3 …