Target of rapamycin (TOR) in nutrient signaling and growth control
Abstract TOR (T arget O f R apamycin) is a highly conserved protein kinase that is important
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive,
central controller of cell growth and aging. In clinical biology, TOR is implicated in many
diseases and is the target of the drug rapamycin used in three different therapeutic areas.
The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of
TOR and the elucidation of its function. Here we review the TOR signaling network in S …
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive,
central controller of cell growth and aging. In clinical biology, TOR is implicated in many
diseases and is the target of the drug rapamycin used in three different therapeutic areas.
The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of
TOR and the elucidation of its function. Here we review the TOR signaling network in S …
Abstract
TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.
Oxford University Press