[HTML][HTML] HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity
Reversible acetylation of lysine residues within a protein is considered a biologically
relevant modification that rivals phosphorylation (Kouzarides, T.(2000) EMBO J. 19, 1176-
1179). The enzymes responsible for such protein modification are called histone
acetyltransferases (HATs) and deacetylases (HDACs). A role of protein phosphorylation in
regulating muscle contraction is well established (Solaro, RJ, Moir, AJ, and Perry, SV (1976)
Nature 262, 615-617). Here we show that reversible protein acetylation carried out by HATs …
relevant modification that rivals phosphorylation (Kouzarides, T.(2000) EMBO J. 19, 1176-
1179). The enzymes responsible for such protein modification are called histone
acetyltransferases (HATs) and deacetylases (HDACs). A role of protein phosphorylation in
regulating muscle contraction is well established (Solaro, RJ, Moir, AJ, and Perry, SV (1976)
Nature 262, 615-617). Here we show that reversible protein acetylation carried out by HATs …