[HTML][HTML] Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator
SMK Pulukuri, B Gorantla, JS Rao - Journal of biological chemistry, 2007 - ASBMB
Histone acetylation plays an important role in chromatin remodeling and gene expression.
The molecular mechanisms involved in differential regulation of urokinase plasminogen
activator (uPA) gene expression are not fully understood. In this study, we investigated
whether histone deacetylation was involved in repression of uPA expression in human
cancer cells. Induction of uPA expression by histone deacetylase (HDAC) inhibitors
trichostatin A (TSA), sodium butyrate, and scriptaid was observed in all three different types …
The molecular mechanisms involved in differential regulation of urokinase plasminogen
activator (uPA) gene expression are not fully understood. In this study, we investigated
whether histone deacetylation was involved in repression of uPA expression in human
cancer cells. Induction of uPA expression by histone deacetylase (HDAC) inhibitors
trichostatin A (TSA), sodium butyrate, and scriptaid was observed in all three different types …