A wide array of recurrent, non-random chromosomal translocations are associated with
hematologic malignancies; experimental models have clearly demonstrated that many of
these translocations are causal events during malignant transformation. Translocations
involving the MLL gene are among the most common of these non-random translocations.
Leukemias with MLL translocations have been the topic of intense interest because of the
unusual, biphenotypic immunophenotype of these leukemias, because of the unique clinical …