The SCF ubiquitin ligase: insights into a molecular machine
T Cardozo, M Pagano - Nature reviews Molecular cell biology, 2004 - nature.com
T Cardozo, M Pagano
Nature reviews Molecular cell biology, 2004•nature.comUbiquitin ligases are well suited to regulate molecular networks that operate on a post-
translational timescale. The F-box family of proteins—which are the substrate-recognition
components of the Skp1–Cul1–F-box-protein (SCF) ubiquitin ligase—are important players
in many mammalian functions. Here we explore a unifying and structurally detailed view of
SCF-mediated proteolytic control of cellular processes that has been revealed by recent
studies.
translational timescale. The F-box family of proteins—which are the substrate-recognition
components of the Skp1–Cul1–F-box-protein (SCF) ubiquitin ligase—are important players
in many mammalian functions. Here we explore a unifying and structurally detailed view of
SCF-mediated proteolytic control of cellular processes that has been revealed by recent
studies.
Abstract
Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins — which are the substrate-recognition components of the Skp1–Cul1–F-box-protein (SCF) ubiquitin ligase — are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.
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