Homology between Epstein-Barr virus DNA and viral DNA from Burkitt's lymphoma and nasopharyngeal carcinoma determined by DNA-DNA reassociation kinetics
M Nonoyama, JS Pagano - Nature, 1973 - nature.com
M Nonoyama, JS Pagano
Nature, 1973•nature.comTHE detection of Epstein-Barr virus (EBV) DNA in established lines of lymphocytes and in
biopsies of Burkitt's lymphoma and nasopharyngeal carcinoma has been reported1–4. The
average number of EBV genomes associated with virus nonproductive cells was estimated
as forty to one hundred per cell by a nucleic acid hybridization technique with EBV-specific
complementary RNA (cRNA) and cellular DNA3, 4, whereas two to five genomes per cell
were found by DNA–DNA hybridization on nitrocellulose filters1, 2.
biopsies of Burkitt's lymphoma and nasopharyngeal carcinoma has been reported1–4. The
average number of EBV genomes associated with virus nonproductive cells was estimated
as forty to one hundred per cell by a nucleic acid hybridization technique with EBV-specific
complementary RNA (cRNA) and cellular DNA3, 4, whereas two to five genomes per cell
were found by DNA–DNA hybridization on nitrocellulose filters1, 2.
Abstract
THE detection of Epstein-Barr virus (EBV) DNA in established lines of lymphocytes and in biopsies of Burkitt's lymphoma and nasopharyngeal carcinoma has been reported1–4. The average number of EBV genomes associated with virus nonproductive cells was estimated as forty to one hundred per cell by a nucleic acid hybridization technique with EBV-specific complementary RNA (cRNA) and cellular DNA3,4, whereas two to five genomes per cell were found by DNA–DNA hybridization on nitrocellulose filters1,2.
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