[HTML][HTML] Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor
JE Sadler, U Budde, JCJ Eikenboom… - Journal of thrombosis …, 2006 - Elsevier
Summary von Willebrand disease (VWD) is a bleeding disorder caused by inherited defects
in the concentration, structure, or function of von Willebrand factor (VWF). VWD is classified
into three primary categories. Type 1 includes partial quantitative deficiency, type 2 includes
qualitative defects, and type 3 includes virtually complete deficiency of VWF. VWD type 2 is
divided into four secondary categories. Type 2A includes variants with decreased platelet
adhesion caused by selective deficiency of high‐molecular‐weight VWF multimers. Type 2B …
in the concentration, structure, or function of von Willebrand factor (VWF). VWD is classified
into three primary categories. Type 1 includes partial quantitative deficiency, type 2 includes
qualitative defects, and type 3 includes virtually complete deficiency of VWF. VWD type 2 is
divided into four secondary categories. Type 2A includes variants with decreased platelet
adhesion caused by selective deficiency of high‐molecular‐weight VWF multimers. Type 2B …