Knowledge on heritable changes in gene expression that result from epigenetic events is of
increasing relevance in the development of strategies for prevention, early diagnosis and
treatment of cancer. Histone acetylation and DNA methylation are epigenetic modifications
whose patterns can be regarded as heritable marks that ensure accurate transmission of the
chromatin states and gene expression profiles over many cell generations. Importantly,
patterns and levels of DNA methylation and histone acetylation are profoundly altered in …