Repopulation of cancer cells during therapy: an important cause of treatment failure
JJ Kim, IF Tannock - Nature Reviews Cancer, 2005 - nature.com
JJ Kim, IF Tannock
Nature Reviews Cancer, 2005•nature.comRadiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow
the recovery of normal tissues between treatments. However, surviving cancer cells also
proliferate during the intervals between treatments and this process of repopulation is an
important cause of treatment failure. Strategies developed to overcome repopulation have
improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in
parallel with advances in the understanding of underlying biological mechanisms.
the recovery of normal tissues between treatments. However, surviving cancer cells also
proliferate during the intervals between treatments and this process of repopulation is an
important cause of treatment failure. Strategies developed to overcome repopulation have
improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in
parallel with advances in the understanding of underlying biological mechanisms.
Abstract
Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in parallel with advances in the understanding of underlying biological mechanisms.
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