[HTML][HTML] Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor α-chain in normal human …
JG Zhang, Y Zhang, CM Owczarek, LD Ward… - Journal of Biological …, 1998 - ASBMB
Leukemia inhibitory factor (LIF) is a polyfunctional cytokine known to require at least two
distinct receptor components (LIF receptor α-chain and gp130) in order to form a high
affinity, functional receptor complex. In this report, we present evidence that there are two
distinct truncated forms of gp130 in normal human urine and plasma: a large form with a
molecular weight of approximately 100,000, which is similar to a previously described form
of soluble gp130 in human serum, and a previously undescribed small form with a molecular …
distinct receptor components (LIF receptor α-chain and gp130) in order to form a high
affinity, functional receptor complex. In this report, we present evidence that there are two
distinct truncated forms of gp130 in normal human urine and plasma: a large form with a
molecular weight of approximately 100,000, which is similar to a previously described form
of soluble gp130 in human serum, and a previously undescribed small form with a molecular …